Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other indicators from the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic experiments have identified recurrent mutations in genes regulating tumor cell-microenvironment interacti... https://theodorek319fov6.shoutmyblog.com/profile