Sedative medicines for example benzodiazepines or similar medication: The concomitant use of opioids with sedative medicines including benzodiazepines or associated medicine improves the hazard of sedation, respiratory depression, coma and death as a result of additive CNS depressant outcome. The dose and length of concomitant use should be confined (see https://katef880sco7.wikiannouncing.com/user