Irregular activation in the Wnt/β-catenin pathway encourages CSC development and thus brings about the deterioration and metastasis of cancer [129]. For example, abnormal activation of Wnt signaling disrupted the conventional advancement and differentiation of colonic crypt stem cells, resulting in a colorectal CSC phenotype by upregulating expression of concentrate on https://charlest999piz0.ssnblog.com/profile