Investigation into conolidine has triggered discovery of the opioid receptor in the body named ACKR3/CXCR7. ACKR3 is apparently the most sought after target for conolidine, which also disregards another 4 classical opioid receptors(3). Conolidine has long been present in the tabernaemontana divaricata plant, that is while in the Apocynaceae https://tvsocialnews.com/story6420002/not-known-factual-statements-about-conoldine-alternative-natural-pain-relief